1. Catalog
  2. Nodes
  3. bp(GO:"response to misfolded protein")

bp(GO:"response to misfolded protein")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
response to misfolded protein
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 1

The Biology of Proteostasis in Aging and Disease v1.0.0

In-Edges 2

act(p(HBP:"N-terminal fragment of ATF6"), ma(tscript)) increases bp(GO:"response to misfolded protein") View Subject | View Object

The cytosolic N-terminal fragment of ATF6 that is generated translocates to the nucleus, binds DNA, and drives expression of a complementary set of UPR genes (8). PubMed:25784053

Appears in Networks:

act(p(HGNC:XBP1), ma(tscript)) increases bp(GO:"response to misfolded protein") View Subject | View Object

This process allows active IRE1 to cleave XBP1 messenger RNA (mRNA), thereby generating a spliced transcript (XBP1s) that encodes a stable form of XBP1 that binds DNA and induces transcription of UPR target genes (8). PubMed:25784053

Appears in Networks:

Out-Edges 2

bp(GO:"response to misfolded protein") increases act(p(HGNC:HSF1)) View Subject | View Object

Upon increased levels of nonnative proteins, HSF1 is released from its repressive complex, acquires DNA-binding activity through homotrimerization, and rapidly translocates to the nucleus to induce expression of genes encoding molecular chaperones (7, 35). PubMed:25784053

Appears in Networks:

bp(GO:"response to misfolded protein") increases act(p(HGNC:ERN1), ma(kin)) View Subject | View Object

IRE1 is a transmembrane protein with kinase and endoribonuclease (RNase) activity that senses misfolding in the ER directly, leading to autophosphorylation, oligomerization, and acquisition of RNase activity (8). PubMed:25784053

Appears in Networks:
Annotations
MeSH
Endoplasmic Reticulum

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.