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complex(a(CHEBI:methyllycaconitine), p(HGNC:CHRNA7))

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Components

Appears in Networks 1

Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. v1.0.0

In-Edges 1

complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:methyllycaconitine), p(HGNC:CHRNA7)) View Subject | View Object

In contrast, Small et al. (2007) found no displacement of alpha-BTX from SH-SY5Y cells (a cell line very closely related to that used by Wang et al.) by either amyloid or methyllycaconitine. Wang et al. (2000b) also showed similar staining of human AD cortical neurons by alpha7 and Abeta antibodies in double immunofluorescence, suggesting that in human cortical neurons, alpha7 and Abeta are closely associated, although such an approach does not prove direct binding. However another study (Small et al., 2007) showed no displacement of labeled alpha-bungarotoxin from cell lines expressing rat alpha7 nAChRs. PubMed:19293145

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Annotations
Experimental Factor Ontology (EFO)
SH-SY5Y

Out-Edges 2

complex(a(CHEBI:methyllycaconitine), p(HGNC:CHRNA7)) hasComponent a(CHEBI:methyllycaconitine) View Subject | View Object

Appears in Networks:

complex(a(CHEBI:methyllycaconitine), p(HGNC:CHRNA7)) hasComponent p(HGNC:CHRNA7) View Subject | View Object

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.