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g(NCBIGENE:406950)

Orthologies: 0 | Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
406950
Namespace
ncbigene
Namespace Version
20190224
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/efc856fb009a39e4d284269a6801f79ed3d3cf56/external/ncbigene.belns

Appears in Networks 1

New insights into the role of microRNAs and long noncoding RNAs in most common neurodegenerative diseases v1.0.0

In-Edges 3

a(MESH:"HSP70 Heat-Shock Proteins") negativeCorrelation g(NCBIGENE:406950) View Subject | View Object

By linking to the 3′‐UTR sequence of Hsp70 mRNA, miR‐16‐1 configures Hsp70. Its increase reduces the Hsp70, which in turn boosts the aggregation of α‐synuclein protein, and this increases the incidence of PD. PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

complex(a(MESH:"HSP70 Heat-Shock Proteins"), g(NCBIGENE:406950)) hasComponent g(NCBIGENE:406950) View Subject | View Object

Appears in Networks:

path(MESH:"Parkinson Disease") association g(NCBIGENE:406950) View Subject | View Object

miR‐16‐1 is a case in point that has been seen in some patients with PD.It has been shown to decrease the expression of Hsp70 by increasing the aggregation of the α‐synuclein protein PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

Out-Edges 4

g(NCBIGENE:406950) association path(MESH:"Parkinson Disease") View Subject | View Object

miR‐16‐1 is a case in point that has been seen in some patients with PD.It has been shown to decrease the expression of Hsp70 by increasing the aggregation of the α‐synuclein protein PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

g(NCBIGENE:406950) decreases a(MESH:"HSP70 Heat-Shock Proteins") View Subject | View Object

miR‐16‐1 is a case in point that has been seen in some patients with PD.It has been shown to decrease the expression of Hsp70 by increasing the aggregation of the α‐synuclein protein PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

g(NCBIGENE:406950) negativeCorrelation a(MESH:"HSP70 Heat-Shock Proteins") View Subject | View Object

By linking to the 3′‐UTR sequence of Hsp70 mRNA, miR‐16‐1 configures Hsp70. Its increase reduces the Hsp70, which in turn boosts the aggregation of α‐synuclein protein, and this increases the incidence of PD. PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

g(NCBIGENE:406950) increases a(HBP:"alpha-synuclein aggregates") View Subject | View Object

miR‐16‐1 is a case in point that has been seen in some patients with PD.It has been shown to decrease the expression of Hsp70 by increasing the aggregation of the α‐synuclein protein PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.