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p(HGNC:CHRM2)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
CHRM2
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 4

Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer's disease and schizophrenia. v1.0.0

This file encodes the article Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer’s disease and schizophrenia by Choi et al, 2014

Alzheimer's Disease: Targeting the Cholinergic System v1.0.0

M1 muscarinic acetylcholine receptor in Alzheimer’s disease v1.0.0

This file encodes the article M1 muscarinic acetylcholine receptor in Alzheimer’s disease by Jiang et al, 2014

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications v1.0.0

In-Edges 7

complex(p(HGNC:CHRM2), p(HGNC:GNAI1)) hasComponent p(HGNC:CHRM2) View Subject | View Object

Appears in Networks:

p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") hasMember p(HGNC:CHRM2) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRM2), p(INTERPRO:"G-protein alpha subunit, group I")) hasComponent p(HGNC:CHRM2) View Subject | View Object

Appears in Networks:

a(MESH:Hippocampus) association p(HGNC:CHRM2) View Subject | View Object

M2 mAChR is expressed throughout the brain, including the hippocampus and neocortex, and is abundant in non-cholinergic neurons that project to these areas. In the caudate-putamen, M2 mAChR acts as an inhibitory modulator on dopaminergic terminals[46-48]. PubMed:24590577

Appears in Networks:

a(MESH:Neocortex) association p(HGNC:CHRM2) View Subject | View Object

M2 mAChR is expressed throughout the brain, including the hippocampus and neocortex, and is abundant in non-cholinergic neurons that project to these areas. In the caudate-putamen, M2 mAChR acts as an inhibitory modulator on dopaminergic terminals[46-48]. PubMed:24590577

Appears in Networks:

complex(p(HGNC:CHRM2), p(HGNC:GNAO1)) hasComponent p(HGNC:CHRM2) View Subject | View Object

Appears in Networks:

p(GFAM:"Cholinergic receptors muscarinic") hasMember p(HGNC:CHRM2) View Subject | View Object

Appears in Networks:

Out-Edges 5

p(HGNC:CHRM2) decreases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) View Subject | View Object

Moreover, the use of M2 antagonists, such as SCH-57790 and SC-72788, can lead to blockage of M2-mediated inhibition of presynaptic release of ACh, which can activate M1 and nicotinic receptors, ameliorating cognitive impairment in AD PubMed:26813123

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

act(p(HGNC:CHRM2)) increases a(CHEBI:"amyloid-beta") View Subject | View Object

In addition, activation of M2 receptors can cause an increase in Aβ production PubMed:26813123

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:CHRM2) association a(MESH:Hippocampus) View Subject | View Object

M2 mAChR is expressed throughout the brain, including the hippocampus and neocortex, and is abundant in non-cholinergic neurons that project to these areas. In the caudate-putamen, M2 mAChR acts as an inhibitory modulator on dopaminergic terminals[46-48]. PubMed:24590577

Appears in Networks:

p(HGNC:CHRM2) association a(MESH:Neocortex) View Subject | View Object

M2 mAChR is expressed throughout the brain, including the hippocampus and neocortex, and is abundant in non-cholinergic neurons that project to these areas. In the caudate-putamen, M2 mAChR acts as an inhibitory modulator on dopaminergic terminals[46-48]. PubMed:24590577

Appears in Networks:

p(HGNC:CHRM2) decreases act(a(CHEBI:dopamine)) View Subject | View Object

M2 mAChR is expressed throughout the brain, including the hippocampus and neocortex, and is abundant in non-cholinergic neurons that project to these areas. In the caudate-putamen, M2 mAChR acts as an inhibitory modulator on dopaminergic terminals[46-48]. PubMed:24590577

Appears in Networks:
Annotations
MeSH
Neostriatum

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.