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p(MGI:Cdk5r1)

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Entity

Name
Cdk5r1
Namespace
MGI
Namespace Version
20170725
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/namespace/mgi-mouse-genes/mgi-mouse-genes-20170725.belns

Appears in Networks 2

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease v1.0.0

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 4

bp(GO:aging) decreases p(MGI:Cdk5r1) View Subject | View Object

The altered expression of genes involved in the transmembrane receptor protein tyrosine kinase signalling pathway in old mice, namely the downregulation of Cdk5r1, Adamts3 and Fgfr3, indicated possible changes in signalling by lymphangiogenic growth factors in old meningeal LECs (Fig. 2d) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Meninges

act(a(MESH:Neurons)) positiveCorrelation p(MGI:Cdk5r1) View Subject | View Object

Our data showed that CDK5 knock down induced an increase in p35 protein levels and Rac activity in triple transgenic Alzheimer's mice, which correlated with the recovery of cognitive function; these findings confirm that increased p35 and active Rac are involved in neuroprotection. In summary, our data suggest that p35 acts as a mediator of Rho GTPase activity and contributes to the neuroprotection induced by CDK5 RNAi. PubMed:27087442

Appears in Networks:

p(HBP:"APOE e4") increases p(MGI:Cdk5r1) View Subject | View Object

The levels of CDK5, its regulatory subunits (p35 and p25) and calpain (including calpain1 and calpain2), but not GSK3ß, were significantly increased in E4FAD mice compared to E3FAD mice. PubMed:27087442

Appears in Networks:

p(MGI:Cdk5) negativeCorrelation p(MGI:Cdk5r1) View Subject | View Object

Our data showed that CDK5 knock down induced an increase in p35 protein levels and Rac activity in triple transgenic Alzheimer's mice, which correlated with the recovery of cognitive function; these findings confirm that increased p35 and active Rac are involved in neuroprotection. In summary, our data suggest that p35 acts as a mediator of Rho GTPase activity and contributes to the neuroprotection induced by CDK5 RNAi. PubMed:27087442

Appears in Networks:

Out-Edges 2

p(MGI:Cdk5r1) negativeCorrelation p(MGI:Cdk5) View Subject | View Object

Our data showed that CDK5 knock down induced an increase in p35 protein levels and Rac activity in triple transgenic Alzheimer's mice, which correlated with the recovery of cognitive function; these findings confirm that increased p35 and active Rac are involved in neuroprotection. In summary, our data suggest that p35 acts as a mediator of Rho GTPase activity and contributes to the neuroprotection induced by CDK5 RNAi. PubMed:27087442

Appears in Networks:

p(MGI:Cdk5r1) positiveCorrelation act(a(MESH:Neurons)) View Subject | View Object

Our data showed that CDK5 knock down induced an increase in p35 protein levels and Rac activity in triple transgenic Alzheimer's mice, which correlated with the recovery of cognitive function; these findings confirm that increased p35 and active Rac are involved in neuroprotection. In summary, our data suggest that p35 acts as a mediator of Rho GTPase activity and contributes to the neuroprotection induced by CDK5 RNAi. PubMed:27087442

Appears in Networks:

About

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.