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p(HGNC:OTUB1, var("p.Cys91Ala"))

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Entity

Name
OTUB1
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo v1.0.0

In-Edges 1

p(HGNC:OTUB1) hasVariant p(HGNC:OTUB1, var("p.Cys91Ala")) View Subject | View Object

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Out-Edges 3

p(HGNC:OTUB1, var("p.Cys91Ala")) causesNoChange p(HGNC:MAPT, pmod(UbK48)) View Subject | View Object

Analysis of a catalytically dead mutant with a C91A mutation revealed no effect on Lys48-linked polyubiquitination of Tau PubMed:28083634

Appears in Networks:

p(HGNC:OTUB1, var("p.Cys91Ala")) causesNoChange deg(p(HGNC:MAPT)) View Subject | View Object

We found that Tau degradation was significantly impaired in primary neurons infected with Otub1 WT, but not with catalytically dead mutant C91A, compared with GFP control. PubMed:28083634

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p(HGNC:OTUB1, var("p.Cys91Ala")) causesNoChange p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) View Subject | View Object

AAV-driven expression of Otub1-C91A did not increase AT8-positive Tau, in contrast to expression of wild-type Otub1 and the N-terminally truncated form of Otub1. This was demonstrated by immunofluorescence staining (Fig. 6a) and confirmed by biochemical analysis (Fig. 6b). PubMed:28083634

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.