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p(HGNC:MAPT, var("p.Ile308Pro")) decreases a(HBP:"Tau aggregates") View Subject | View Object

In one set of C. elegans strains, we expressed the pathological FDTP-17 mutant DK280, which enhances aggregation, whereas the other set harbours, in addition to DK280, the proline substitutions I277P and I308P (PP), which act as b-sheet breakers and prevent aggregation (15). PubMed:22611162


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