a(CHEBI:"dihydro-beta-erythroidine")

Entity

Name

dihydro-beta-erythroidine

Namespace

chebi

Namespace Version

20180906

Namespace URL

https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Nicotine protection of cultured rat cortical neu- rons against Abeta toxicity is blocked by the alpha4beta2 antagonist, dihydro-beta-erythroidine (Kihara et al., 1998). PubMed:19293145

The discovery that nicotine, a ligand acting at nAChRs, and its mimetics can protect neurons against Abeta toxicity (Kihara et al., 1998) is of interest, especially in view of the observation that nicotine also enhances cognition (Rusted et al., 2000). Nicotinic receptors play a particularly prominent role in nicotine protection. The protective effect is blocked by the nicotinic antagonists dihydro-beta-erythroidine and mecamylamine (Kihara et al., 2001; Takada- Takatori et al., 2006). PubMed:19293145

Nicotine protection of cultured rat cortical neu- rons against Abeta toxicity is blocked by the alpha4beta2 antagonist, dihydro-beta-erythroidine (Kihara et al., 1998). PubMed:19293145

Nicotine protection of cultured rat cortical neu- rons against Abeta toxicity is blocked by the alpha4beta2 antagonist, dihydro-beta-erythroidine (Kihara et al., 1998). PubMed:19293145

For example, local infusion of the α7 antagonist, methyllycaconitine (MLA), or the β2∗ antagonist, dihydro-β-erythroidine (DHβE), into the basolateral amygdala, the ventral hippocampus, or the dorsal hippocampus impairs the working memory of rats seeking food reward within a 16-arm radial maze (146–148). PubMed:17009926

For example, local infusion of the α7 antagonist, methyllycaconitine (MLA), or the β2∗ antagonist, dihydro-β-erythroidine (DHβE), into the basolateral amygdala, the ventral hippocampus, or the dorsal hippocampus impairs the working memory of rats seeking food reward within a 16-arm radial maze (146–148). PubMed:17009926