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p(HGNC:VHL)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
VHL
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies v1.0.0

In-Edges 6

complex(p(FPLX:HSP90), p(HGNC:VHL)) hasComponent p(HGNC:VHL) View Subject | View Object

Appears in Networks:

complex(p(FPLX:HSP90), p(HGNC:VHL)) increases deg(p(HGNC:VHL)) View Subject | View Object

In another example, McClellan et al. showed that von Hippel–Lindau tumor-suppressor protein requires Hsp70 for its folding and degradation, whereas Hsp90 is only required for degradation [149]. PubMed:21882945

Appears in Networks:

complex(p(HGNC:STIP1), p(HGNC:VHL)) hasComponent p(HGNC:VHL) View Subject | View Object

Appears in Networks:

complex(p(HGNC:STIP1), p(HGNC:VHL)) increases deg(p(HGNC:VHL)) View Subject | View Object

HOP was also required for degradation, indicating that transfer of von Hippel–Lindau from the Hsp70 complex to Hsp90 is a necessary part of its degradation pathway. PubMed:21882945

Appears in Networks:

complex(p(HGNC:VHL), p(INTERPRO:"Heat shock protein 70 family")) hasComponent p(HGNC:VHL) View Subject | View Object

Appears in Networks:

complex(p(HGNC:VHL), p(INTERPRO:"Heat shock protein 70 family")) increases deg(p(HGNC:VHL)) View Subject | View Object

In another example, McClellan et al. showed that von Hippel–Lindau tumor-suppressor protein requires Hsp70 for its folding and degradation, whereas Hsp90 is only required for degradation [149]. PubMed:21882945

Appears in Networks:

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.