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M1 muscarinic acetylcholine receptor in Alzheimer’s disease v1.0.0

This file encodes the article M1 muscarinic acetylcholine receptor in Alzheimer’s disease by Jiang et al, 2014

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Out-Edges 5

p(MGI:Chrm3) regulates bp(GO:"response to food") View Subject | View Object

M3 mAChR is expressed at a relatively high level in the hypothalamus, but is also found in many other regions including the hippocampus[47]. Mice lacking M3 mAChR appear hypophagic and lean, suggesting a general function of M2 mAChR in regulating food intake[50]. PubMed:24590577

p(MGI:Chrm3) increases bp(GO:"pituitary gland development") View Subject | View Object

Consistently, mice with conditional knockout of M3 mAChR in the brain exhibit a dwarf phenotype. They also exhibit hypoplasia of the anterior pituitary gland and significantly decreased hormones including pituitary prolactin and growth hormone[51]. These fi ndings indicate that M3 mAChR plays a critical role in promoting body growth. PubMed:24590577

p(MGI:Chrm3) increases p(MGI:Prl) View Subject | View Object

Consistently, mice with conditional knockout of M3 mAChR in the brain exhibit a dwarf phenotype. They also exhibit hypoplasia of the anterior pituitary gland and significantly decreased hormones including pituitary prolactin and growth hormone[51]. These fi ndings indicate that M3 mAChR plays a critical role in promoting body growth. PubMed:24590577

p(MGI:Chrm3) increases p(MGI:Gh) View Subject | View Object

Consistently, mice with conditional knockout of M3 mAChR in the brain exhibit a dwarf phenotype. They also exhibit hypoplasia of the anterior pituitary gland and significantly decreased hormones including pituitary prolactin and growth hormone[51]. These fi ndings indicate that M3 mAChR plays a critical role in promoting body growth. PubMed:24590577

p(MGI:Chrm3) increases bp(GO:"multicellular organism growth") View Subject | View Object

Consistently, mice with conditional knockout of M3 mAChR in the brain exhibit a dwarf phenotype. They also exhibit hypoplasia of the anterior pituitary gland and significantly decreased hormones including pituitary prolactin and growth hormone[51]. These fi ndings indicate that M3 mAChR plays a critical role in promoting body growth. PubMed:24590577

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.