Evidences a(CHEBI:methamphetamine) to bp(GO:autophagy)

In line with this, METH produces ultrastructural alterations reflecting dysfunctional autophagy flux, which are DA-dependent

In fact, mTOR-induced autophagy inhibition exacerbates the ultrastructural effects of METH [126,134–136], while rapamycin administration reverts both behavioral and morphological alterations induced by METH [137].

This confirms our previous studies showing that both genetic and pharmacological autophagy inhibition worsen the effects of METH administration

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.