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complex(a(MESHC:"gambogic amide"), p(HGNC:NTRK1))

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Components

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Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications v1.0.0

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Out-Edges 3

complex(a(MESHC:"gambogic amide"), p(HGNC:NTRK1)) hasComponent a(MESHC:"gambogic amide") View Subject | View Object

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complex(a(MESHC:"gambogic amide"), p(HGNC:NTRK1)) hasComponent p(HGNC:NTRK1) View Subject | View Object

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complex(a(MESHC:"gambogic amide"), p(HGNC:NTRK1)) directlyIncreases p(HGNC:NTRK1, pmod(Ph)) View Subject | View Object

Gambogic amide binds selectively to TrkA (but not TrkB or TrkC), phosphorylates TrkA tyrosine residues, and activates the Akt and MAPK TrkA-mediated NGF signaling pathways. Gambogic amide has been demonstrated to ameliorate excitotoxic damage and promote neurite outgrowth in PC12 cells [116], making this a potential lead compound for chemical modification and clinical trial assessment. PubMed:18986241

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Annotations
MeSH
Cognitive Dysfunction

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.