Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Appears in Networks 1

In-Edges 0

Out-Edges 2

p(HGNC:PLG) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) View Subject | View Object

Like IDE and neprilysin, plasmin degrades Aβ42 and blocks Aβ42-induced toxicity, suggesting that the decrease in its levels in AD is involved in the evolution of AD 254,256,261 . PubMed:30116051

p(HGNC:PLG) increases deg(p(HGNC:SNCA)) View Subject | View Object

Plasmin also degrades α-synuclein to retard intercellular spreading 262 . PubMed:30116051

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.