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complex(p(FPLX:HSP90), p(HGNC:CDC37))

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Components

Appears in Networks 1

Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies v1.0.0

In-Edges 1

a(PUBCHEM:162859) decreases complex(p(FPLX:HSP90), p(HGNC:CDC37)) View Subject | View Object

The Cdc37/Hsp90 inhibitors, Celasterol and Withaferin A (Zhang et al., 2008; Yu et al., 2010), reduce tau levels and a new compound, platycodin D has just been discovered (Li et al., 2017). Platycodin D does not affect the ATPase activity of Hsp90, but instead disrupts the interaction between Hsp90 and Cdc37 leading to client protein degradation without an increase in Hsp70 (Li et al., 2017). PubMed:29311797

Appears in Networks:

Out-Edges 4

complex(p(FPLX:HSP90), p(HGNC:CDC37)) hasComponent p(FPLX:HSP90) View Subject | View Object

Appears in Networks:

complex(p(FPLX:HSP90), p(HGNC:CDC37)) hasComponent p(HGNC:CDC37) View Subject | View Object

Appears in Networks:

complex(p(FPLX:HSP90), p(HGNC:CDC37)) increases p(HGNC:GSK3B) View Subject | View Object

Cdc37 is also required for the stable folding of protein kinases in coordination with Hsp90 (Calderwood, 2015). Many of these kinases are known to phosphorylate tau at sites associated with AD, such as GSK3β and MAPK13 (Taipale et al., 2012; Jin et al., 2016). PubMed:29311797

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

complex(p(FPLX:HSP90), p(HGNC:CDC37)) increases p(HGNC:MAPK13) View Subject | View Object

Cdc37 is also required for the stable folding of protein kinases in coordination with Hsp90 (Calderwood, 2015). Many of these kinases are known to phosphorylate tau at sites associated with AD, such as GSK3β and MAPK13 (Taipale et al., 2012; Jin et al., 2016). PubMed:29311797

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.