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a(HBP:"Tau epitope, AT8")

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Entity

Name
Tau epitope, AT8
Namespace
HBP
Namespace Version
20181119
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/90e1cb9e5e882703380c9db8d4915ac6f3cba137/export/hbp-names.belns

Appears in Networks 2

Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease v1.0.0

Adenosine A1 receptor antagonist 64627 alleviates axonopathy caused by human Tau ΔK280 v1.0.0

In-Edges 3

bp(MESH:Autophagy) decreases a(HBP:"Tau epitope, AT8") View Subject | View Object

Activating autophagy with trehalose in rat cortical neurons demonstrated certain phospho-epitopes (AT8, PHF1, and 12E8) were reduced more significantly than total tau – up to 80% compared to the 20% reduction in total tau (96). PubMed:24027553

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Annotations
Text Location
Review

p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) positiveCorrelation a(HBP:"Tau epitope, AT8") View Subject | View Object

The antibody AT180 (Tau pThr231) (18) shows (very) weak staining in the cell soma of both types of Tau transgenic slices (Fig. 2 G and H, asterisks) contrasting the high degree of Tau phosphorylated at Ser202/Thr205 [asterisks (somata) and long arrows (apical dendrites)] (AT8 antibody, Fig. 2 I and J) PubMed:27671637

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(HBP:"Tau epitope, AT8") View Subject | View Object

The antibody AT180 (Tau pThr231) (18) shows (very) weak staining in the cell soma of both types of Tau transgenic slices (Fig. 2 G and H, asterisks) contrasting the high degree of Tau phosphorylated at Ser202/Thr205 [asterisks (somata) and long arrows (apical dendrites)] (AT8 antibody, Fig. 2 I and J) PubMed:27671637

Appears in Networks:

Out-Edges 2

a(HBP:"Tau epitope, AT8") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) View Subject | View Object

The antibody AT180 (Tau pThr231) (18) shows (very) weak staining in the cell soma of both types of Tau transgenic slices (Fig. 2 G and H, asterisks) contrasting the high degree of Tau phosphorylated at Ser202/Thr205 [asterisks (somata) and long arrows (apical dendrites)] (AT8 antibody, Fig. 2 I and J) PubMed:27671637

Appears in Networks:

a(HBP:"Tau epitope, AT8") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) View Subject | View Object

The antibody AT180 (Tau pThr231) (18) shows (very) weak staining in the cell soma of both types of Tau transgenic slices (Fig. 2 G and H, asterisks) contrasting the high degree of Tau phosphorylated at Ser202/Thr205 [asterisks (somata) and long arrows (apical dendrites)] (AT8 antibody, Fig. 2 I and J) PubMed:27671637

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.