p(MGI:Mapt, pmod(HBP:hyperphosphorylation))

Entity

Name

Mapt

Namespace

mgi

Namespace Version

20181021

Namespace URL

https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Tau Modifications Sections of NESTOR

In this study, we demonstrated that GLP-1RA could inhibit oxidative stress and repair mitochondrial damage in addition to decreasing tau hyperphosphorylation in PC12 cells treated with AGEs. Importantly, we first observed AGEs in the circulatory system could induce tau hyperphosphorylation after we injected AGEs (1μg/kg bodyweight) into the mice tail vein. We found GLP-1RA could promote mitochondrial biogenesis and antioxidant system via regulating peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) signaling pathway in vivo besides down-regulating the activity of glycogen synthase kinase 3β (GSK-3β) to reverse tau hyperphosphorylation directly. PubMed:25987199

We found strong Tau hyperphosphorylation in brain samples from R6/2 and 140CAG Tg knock-in, associated with a significant reduction in the levels of Tau phosphatases (PP1, PP2A and PP2B), with no apparent involvement of major Tau kinases. PubMed:25143394

We found strong Tau hyperphosphorylation in brain samples from R6/2 and 140CAG Tg knock-in, associated with a significant reduction in the levels of Tau phosphatases (PP1, PP2A and PP2B), with no apparent involvement of major Tau kinases. PubMed:25143394

We found strong Tau hyperphosphorylation in brain samples from R6/2 and 140CAG Tg knock-in, associated with a significant reduction in the levels of Tau phosphatases (PP1, PP2A and PP2B), with no apparent involvement of major Tau kinases. PubMed:25143394

PP2A expression decreased, whereas, PP1 and PP5 expression increased in lead-exposed rats. These results demonstrate that early postnatal exposure to lead decrease PP2A expression and induce tau hyperphosphorylation at several serine and threonine residues. PubMed:23134599

We found strong Tau hyperphosphorylation in brain samples from R6/2 and 140CAG Tg knock-in, associated with a significant reduction in the levels of Tau phosphatases (PP1, PP2A and PP2B), with no apparent involvement of major Tau kinases. PubMed:25143394

We found strong Tau hyperphosphorylation in brain samples from R6/2 and 140CAG Tg knock-in, associated with a significant reduction in the levels of Tau phosphatases (PP1, PP2A and PP2B), with no apparent involvement of major Tau kinases. PubMed:25143394

We found strong Tau hyperphosphorylation in brain samples from R6/2 and 140CAG Tg knock-in, associated with a significant reduction in the levels of Tau phosphatases (PP1, PP2A and PP2B), with no apparent involvement of major Tau kinases. PubMed:25143394

PP2A expression decreased, whereas, PP1 and PP5 expression increased in lead-exposed rats. These results demonstrate that early postnatal exposure to lead decrease PP2A expression and induce tau hyperphosphorylation at several serine and threonine residues. PubMed:23134599