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p(MGI:Mapt, pmod(Ph, Ser, 235))

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Entity

Name
Mapt
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 1

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 3

p(MGI:Mapt) hasVariant p(MGI:Mapt, pmod(Ph, Ser, 235)) View Subject | View Object

Appears in Networks:

act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 235)) View Subject | View Object

Nuclear factor erythroid-2-related factor 2 (Nrf2) is a transcription factor known to increase the level of many antioxidants, including glutathione-S transferase (GST), and is negatively regulated by the activity of GSK-3β. Our results indicated the increased nuclear localization of Nrf2 and level of GST, suggesting the increased activity of the transcription factor as a result of GSK-3β suppression, consistent with the decreased oxidative stress observed. Consistent with the improved learning and memory, and consistent with GSK-3b being a tau kinase, we observed decreased tau phosphorylation in brain of GAO-treated SAMP8 mice compared to that of RAO-treated SAMP8 mice. PubMed:24355211

Appears in Networks:

act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 235)) View Subject | View Object

Tau peptides containing phosphorylated S202, T205, and T396 were found only in Tg mice, supporting our results using AT8 and PHF1 antibodies PubMed:14642273

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Out-Edges 0

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.