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p(FPLX:PPAR)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
PPAR
Namespace
FAMPLEX
Namespace Version
20180612
Namespace URL
https://raw.githubusercontent.com/sorgerlab/famplex/1b7e14ec0fd02ee7ed71514c6e267f57d5641a4b/export/famplex.belns

Appears in Networks 1

Nuclear receptors as therapeutic targets for Alzheimer's disease. v1.0.0

In-Edges 9

bp(GO:"fat cell differentiation") association p(FPLX:PPAR) View Subject | View Object

PPARs have been shown to play essential roles in energy metabolism, adipocyte differentiation, insulin sensitization and tumor suppression. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

bp(GO:"fat cell differentiation") positiveCorrelation p(FPLX:PPAR) View Subject | View Object

PPARs have been shown to play essential roles in energy metabolism, adipocyte differentiation, insulin sensitization and tumor suppression. PubMed:21718217

Appears in Networks:
Annotations
Confidence
Medium

bp(GO:"response to insulin") association p(FPLX:PPAR) View Subject | View Object

PPARs have been shown to play essential roles in energy metabolism, adipocyte differentiation, insulin sensitization and tumor suppression. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

bp(GO:"response to insulin") positiveCorrelation p(FPLX:PPAR) View Subject | View Object

PPARs have been shown to play essential roles in energy metabolism, adipocyte differentiation, insulin sensitization and tumor suppression. PubMed:21718217

Appears in Networks:
Annotations
Confidence
Medium

bp(GO:"response to tumor cell") association p(FPLX:PPAR) View Subject | View Object

PPARs have been shown to play essential roles in energy metabolism, adipocyte differentiation, insulin sensitization and tumor suppression. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

bp(GO:"response to tumor cell") positiveCorrelation p(FPLX:PPAR) View Subject | View Object

PPARs have been shown to play essential roles in energy metabolism, adipocyte differentiation, insulin sensitization and tumor suppression. PubMed:21718217

Appears in Networks:
Annotations
Confidence
Medium

bp(MESH:"Energy Metabolism") association p(FPLX:PPAR) View Subject | View Object

PPARs have been shown to play essential roles in energy metabolism, adipocyte differentiation, insulin sensitization and tumor suppression. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

bp(MESH:"Energy Metabolism") positiveCorrelation p(FPLX:PPAR) View Subject | View Object

PPARs have been shown to play essential roles in energy metabolism, adipocyte differentiation, insulin sensitization and tumor suppression. PubMed:21718217

Appears in Networks:
Annotations
Confidence
Medium

complex(p(FPLX:PPAR), p(FPLX:RXR)) hasComponent p(FPLX:PPAR) View Subject | View Object

Appears in Networks:

Out-Edges 10

p(FPLX:PPAR) association bp(MESH:"Energy Metabolism") View Subject | View Object

PPARs have been shown to play essential roles in energy metabolism, adipocyte differentiation, insulin sensitization and tumor suppression. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

p(FPLX:PPAR) positiveCorrelation bp(MESH:"Energy Metabolism") View Subject | View Object

PPARs have been shown to play essential roles in energy metabolism, adipocyte differentiation, insulin sensitization and tumor suppression. PubMed:21718217

Appears in Networks:
Annotations
Confidence
Medium

p(FPLX:PPAR) association bp(GO:"fat cell differentiation") View Subject | View Object

PPARs have been shown to play essential roles in energy metabolism, adipocyte differentiation, insulin sensitization and tumor suppression. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

p(FPLX:PPAR) positiveCorrelation bp(GO:"fat cell differentiation") View Subject | View Object

PPARs have been shown to play essential roles in energy metabolism, adipocyte differentiation, insulin sensitization and tumor suppression. PubMed:21718217

Appears in Networks:
Annotations
Confidence
Medium

p(FPLX:PPAR) association bp(GO:"response to insulin") View Subject | View Object

PPARs have been shown to play essential roles in energy metabolism, adipocyte differentiation, insulin sensitization and tumor suppression. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

p(FPLX:PPAR) positiveCorrelation bp(GO:"response to insulin") View Subject | View Object

PPARs have been shown to play essential roles in energy metabolism, adipocyte differentiation, insulin sensitization and tumor suppression. PubMed:21718217

Appears in Networks:
Annotations
Confidence
Medium

p(FPLX:PPAR) association bp(GO:"response to tumor cell") View Subject | View Object

PPARs have been shown to play essential roles in energy metabolism, adipocyte differentiation, insulin sensitization and tumor suppression. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

p(FPLX:PPAR) positiveCorrelation bp(GO:"response to tumor cell") View Subject | View Object

PPARs have been shown to play essential roles in energy metabolism, adipocyte differentiation, insulin sensitization and tumor suppression. PubMed:21718217

Appears in Networks:
Annotations
Confidence
Medium

p(FPLX:PPAR) regulates bp(GO:"lipid metabolic process") View Subject | View Object

They act as dominant regulators of lipid metabolism through their ability to transactivate genes encoding enzymes of lipid metabolism, providing a key linkage between the diet and the genome. PubMed:21718217

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Microglia

act(p(FPLX:PPAR)) decreases bp(GO:"microglial cell activation") View Subject | View Object

Indeed, treatment of AD mouse models with LXR or PPAR agonists has resulted in the suppression of microglial activation [44,45,47,59,63]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.