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energy homeostasis
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albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

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a(CHEBI:lipid) regulates bp(GO:"energy homeostasis") View Subject | View Object

In addition to their structural role in membranes, lipids are essential in the maintenance of cellular energy homeostasis as well as regulation of intracellular signaling pathways PubMed:29758300

a(GO:mitochondrion) regulates bp(GO:"energy homeostasis") View Subject | View Object

Mitochondria are instrumental in the regulation of energy metabolism, and impairment in mitochondrial function has been implicated in the pathogenesis of AD, leading to the mitochondrial cascade hypothesis of AD [121]. PubMed:29758300

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bp(GO:"energy homeostasis") regulates a(CHEBI:"kynurenic acid") View Subject | View Object

Interestingly, astrocytic KYNA production is regulated by neuronal activity (187) and cellular energy metabolism (213). This dependence of extracellular KYNA concentrations on the functional interplay between neurons and astrocytes is in line with the postulated neuromodulatory role of KYNA (418) and adds to the complexity of the neurochemical networks in the brain. PubMed:19126755

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