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complex(a(CHEBI:epibatidine), a(HBP:HBP00174))

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Components

Appears in Networks 1

NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain v1.0.0

In-Edges 2

act(p(HGNC:TMEM35A), ma(chap)) increases complex(a(CHEBI:epibatidine), a(HBP:HBP00174)) View Subject | View Object

Cells transfected with alpha4beta2 or alpha3beta4 alone showed [3H]epibatidine binding, and this was markedly increased (5- to 10-fold) in presence of NACHO (Figures 2B and 2D) PubMed:28445721

Appears in Networks:

p(MGI:Tmem35a) increases complex(a(CHEBI:epibatidine), a(HBP:HBP00174)) View Subject | View Object

This partial reduction fits with our data showing that NACHO enhances [3H]epibatidine binding to alpha4beta2 and other heteromeric nAChRs but that some [3H]epibatidine binding occurs to certain heteromeric nAChRs in the absence of NACHO (Figure 2B) PubMed:28445721

Appears in Networks:

Out-Edges 2

complex(a(CHEBI:epibatidine), a(HBP:HBP00174)) hasComponent a(CHEBI:epibatidine) View Subject | View Object

Appears in Networks:

complex(a(CHEBI:epibatidine), a(HBP:HBP00174)) hasComponent a(HBP:HBP00174) View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.