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p(HGNC:BAG1)

Equivalencies: 0 | Classes: 1 | Children: 0 | Explore

Entity

Name
BAG1
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 4

A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways v1.0.0

Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies v1.0.0

TAU and Interaction Partners v1.2.5

TAU Interactions Section of NESTOR

Molecular Chaperone Functions in Protein Folding and Proteostasis v1.0.0

In-Edges 13

complex(p(HGNC:BAG1), p(HGNC:HSPA8)) hasComponent p(HGNC:BAG1) View Subject | View Object

Appears in Networks:

complex(p(HGNC:BAG1), p(HGNC:LTN1)) hasComponent p(HGNC:BAG1) View Subject | View Object

Appears in Networks:

complex(p(HGNC:BAG1), p(HGNC:PSMA5)) hasComponent p(HGNC:BAG1) View Subject | View Object

Appears in Networks:

complex(p(HGNC:BAG1), p(HGNC:PSMC4)) hasComponent p(HGNC:BAG1) View Subject | View Object

Appears in Networks:

complex(p(HGNC:BAG1), p(HGNC:PSMD2)) hasComponent p(HGNC:BAG1) View Subject | View Object

Appears in Networks:

complex(p(HGNC:BAG1), p(HGNC:MAPT)) hasComponent p(HGNC:BAG1) View Subject | View Object

Appears in Networks:

complex(p(HGNC:BAG1), p(INTERPRO:"Heat shock protein 70 family")) hasComponent p(HGNC:BAG1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:BAG1) View Subject | View Object

BAG1 is upregulated in the hippocampus of AD patients [130], where it associates with tau and increases tau levels in cooperation with Hsp70 [131] PubMed:21882945

Appears in Networks:
Annotations
MeSH
Hippocampus

act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:BAG1) View Subject | View Object

We further show that BAG-1 can inhibit the degradation of Tau protein by the 20 S proteasome but does not affect the ubiquitination of Tau protein.RNA-me- diated interference depletion of BAG-1 leads to a decrease in total Tau protein levels as well as promoting hyperphosphorylation of the remaining protein. PubMed:17954934

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
MeSH
Hippocampus

p(HGNC:MAPT) positiveCorrelation p(HGNC:BAG1) View Subject | View Object

We further show that BAG-1 can inhibit the degradation of Tau protein by the 20 S proteasome but does not affect the ubiquitination of Tau protein.RNA-me- diated interference depletion of BAG-1 leads to a decrease in total Tau protein levels as well as promoting hyperphosphorylation of the remaining protein. PubMed:17954934

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
MeSH
Hippocampus

complex(p(HGNC:BAG1), p(HGNC:MAPT), p(HGNC:STUB1)) hasComponent p(HGNC:BAG1) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ph)) negativeCorrelation p(HGNC:BAG1) View Subject | View Object

We further show that BAG-1 can inhibit the degradation of Tau protein by the 20 S proteasome but does not affect the ubiquitination of Tau protein.RNA-me- diated interference depletion of BAG-1 leads to a decrease in total Tau protein levels as well as promoting hyperphosphorylation of the remaining protein. PubMed:17954934

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
MeSH
Hippocampus

composite(p(FPLX:HSP90), p(FPLX:HSPA), p(HGNC:BAG1), p(HGNC:BAG3), p(HGNC:STUB1)) hasComponent p(HGNC:BAG1) View Subject | View Object

Appears in Networks:

Out-Edges 13

p(HGNC:BAG1) increases complex(p(HGNC:BAG1), p(HGNC:LTN1)) View Subject | View Object

BAG1 interacted with the E3 ubiquitin ligase Listerin (LTN1), which is involved in ribosomal quality control (RQC) of stalled polypeptides (Bengtson and Joazeiro, 2010). PubMed:25036637

Appears in Networks:

p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMA5)) View Subject | View Object

BAG3 and BAG4 showed a strong association only with the small heat shock protein Hsp27 (Figure 5F) and the mRNA decapping complex member DCP1B, respectively (Figure 5G), whereas BAG1 interacted with several proteasome subunits (Figure S4C) PubMed:25036637

Appears in Networks:

p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMC4)) View Subject | View Object

BAG3 and BAG4 showed a strong association only with the small heat shock protein Hsp27 (Figure 5F) and the mRNA decapping complex member DCP1B, respectively (Figure 5G), whereas BAG1 interacted with several proteasome subunits (Figure S4C) PubMed:25036637

Appears in Networks:

p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMD2)) View Subject | View Object

BAG3 and BAG4 showed a strong association only with the small heat shock protein Hsp27 (Figure 5F) and the mRNA decapping complex member DCP1B, respectively (Figure 5G), whereas BAG1 interacted with several proteasome subunits (Figure S4C) PubMed:25036637

Appears in Networks:

p(HGNC:BAG1) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

BAG1 is upregulated in the hippocampus of AD patients [130], where it associates with tau and increases tau levels in cooperation with Hsp70 [131] PubMed:21882945

Appears in Networks:
Annotations
MeSH
Hippocampus

p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:MAPT)) View Subject | View Object

BAG1 is upregulated in the hippocampus of AD patients [130], where it associates with tau and increases tau levels in cooperation with Hsp70 [131] PubMed:21882945

Appears in Networks:
Annotations
MeSH
Hippocampus

p(HGNC:BAG1) decreases deg(p(HGNC:MAPT)) View Subject | View Object

BAG1 silencing decreases tau levels, consistent with a critical role for this co-chaperone in protecting tau from degradation. PubMed:21882945

Appears in Networks:

p(HGNC:BAG1) isA complex(p(HGNC:BAG1), p(HGNC:MAPT), p(HGNC:STUB1)) View Subject | View Object

Appears in Networks:

p(HGNC:BAG1) positiveCorrelation p(HGNC:MAPT) View Subject | View Object

We further show that BAG-1 can inhibit the degradation of Tau protein by the 20 S proteasome but does not affect the ubiquitination of Tau protein.RNA-me- diated interference depletion of BAG-1 leads to a decrease in total Tau protein levels as well as promoting hyperphosphorylation of the remaining protein. PubMed:17954934

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
MeSH
Hippocampus

p(HGNC:BAG1) decreases deg(p(HGNC:MAPT)) View Subject | View Object

We further show that BAG-1 can inhibit the degradation of Tau protein by the 20 S proteasome but does not affect the ubiquitination of Tau protein.RNA-me- diated interference depletion of BAG-1 leads to a decrease in total Tau protein levels as well as promoting hyperphosphorylation of the remaining protein. PubMed:17954934

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
MeSH
Hippocampus

p(HGNC:BAG1) negativeCorrelation act(complex(GO:"proteasome complex")) View Subject | View Object

We further show that BAG-1 can inhibit the degradation of Tau protein by the 20 S proteasome but does not affect the ubiquitination of Tau protein.RNA-me- diated interference depletion of BAG-1 leads to a decrease in total Tau protein levels as well as promoting hyperphosphorylation of the remaining protein. PubMed:17954934

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
MeSH
Hippocampus

p(HGNC:BAG1) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

We further show that BAG-1 can inhibit the degradation of Tau protein by the 20 S proteasome but does not affect the ubiquitination of Tau protein.RNA-me- diated interference depletion of BAG-1 leads to a decrease in total Tau protein levels as well as promoting hyperphosphorylation of the remaining protein. PubMed:17954934

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
MeSH
Hippocampus

p(HGNC:BAG1) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") View Subject | View Object

BAG1 targets proteins for degradation by the UPS, whereas BAG3 mediates degradation by macroautophagy. PubMed:23746257

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.