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complex(p(HGNC:APBA1), p(HGNC:APP))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Components

Appears in Networks 1

APP processing in Alzheimer's disease v1.0.1

APP processing in Alzheimer's disease

In-Edges 4

a(CHEBI:"amyloid-beta") association complex(p(HGNC:APBA1), p(HGNC:APP)) View Subject | View Object

APP interaction with mint proteins has been shown to affect APP processing by stabilizing cellular APP, altering both sAPPalpha and Abeta generation and secretion [166] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
High
MeSH
Hippocampus
MeSH
Down Syndrome

sec(a(CHEBI:"amyloid-beta")) association complex(p(HGNC:APBA1), p(HGNC:APP)) View Subject | View Object

APP interaction with mint proteins has been shown to affect APP processing by stabilizing cellular APP, altering both sAPPalpha and Abeta generation and secretion [166] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
High
MeSH
Hippocampus
MeSH
Down Syndrome

a(HBP:HBP00067) association complex(p(HGNC:APBA1), p(HGNC:APP)) View Subject | View Object

APP interaction with mint proteins has been shown to affect APP processing by stabilizing cellular APP, altering both sAPPalpha and Abeta generation and secretion [166] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
High
MeSH
Hippocampus
MeSH
Down Syndrome

sec(a(HBP:HBP00067)) association complex(p(HGNC:APBA1), p(HGNC:APP)) View Subject | View Object

APP interaction with mint proteins has been shown to affect APP processing by stabilizing cellular APP, altering both sAPPalpha and Abeta generation and secretion [166] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
High
MeSH
Hippocampus
MeSH
Down Syndrome

Out-Edges 7

complex(p(HGNC:APBA1), p(HGNC:APP)) hasComponent p(HGNC:APBA1) View Subject | View Object

Appears in Networks:

complex(p(HGNC:APBA1), p(HGNC:APP)) hasComponent p(HGNC:APP) View Subject | View Object

Appears in Networks:

complex(p(HGNC:APBA1), p(HGNC:APP)) regulates bp(GO:"protein transport") View Subject | View Object

For example, the APP C-terminus has been found to interact with all three mint (X11) family members (mint1, mint2, and mint3) involved in trafficking regulation [163-165] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
High
MeSH
Hippocampus
MeSH
Down Syndrome

complex(p(HGNC:APBA1), p(HGNC:APP)) association a(HBP:HBP00067) View Subject | View Object

APP interaction with mint proteins has been shown to affect APP processing by stabilizing cellular APP, altering both sAPPalpha and Abeta generation and secretion [166] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
High
MeSH
Hippocampus
MeSH
Down Syndrome

complex(p(HGNC:APBA1), p(HGNC:APP)) association sec(a(HBP:HBP00067)) View Subject | View Object

APP interaction with mint proteins has been shown to affect APP processing by stabilizing cellular APP, altering both sAPPalpha and Abeta generation and secretion [166] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
High
MeSH
Hippocampus
MeSH
Down Syndrome

complex(p(HGNC:APBA1), p(HGNC:APP)) association a(CHEBI:"amyloid-beta") View Subject | View Object

APP interaction with mint proteins has been shown to affect APP processing by stabilizing cellular APP, altering both sAPPalpha and Abeta generation and secretion [166] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
High
MeSH
Hippocampus
MeSH
Down Syndrome

complex(p(HGNC:APBA1), p(HGNC:APP)) association sec(a(CHEBI:"amyloid-beta")) View Subject | View Object

APP interaction with mint proteins has been shown to affect APP processing by stabilizing cellular APP, altering both sAPPalpha and Abeta generation and secretion [166] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
High
MeSH
Hippocampus
MeSH
Down Syndrome

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.