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a(HBP:"Pathological Tau Spreading")

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Entity

Name
Pathological Tau Spreading
Namespace
HBP
Namespace Version
20181119
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/90e1cb9e5e882703380c9db8d4915ac6f3cba137/export/hbp-names.belns

Appears in Networks 1

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 2

a(HBP:"Tau oligomers") increases a(HBP:"Pathological Tau Spreading") View Subject | View Object

This work supports the hypothesis that tau oligomers are toxic species that can drive the spread of tau pathology and neurodegeneration. PubMed:27716675

Appears in Networks:

act(p(HGNC:SIRT1)) negativeCorrelation a(HBP:"Pathological Tau Spreading") View Subject | View Object

SIRT1 deficiency exacerbates premature mortality, synapse loss, and behavioral disinhibition in tauP301S TG mice of both sexes. SIRT1 overexpression into the hippocampus reduces acetylated K174 tau and significantly attenuates the spread of tau pathology into anatomically connected brain regions of tauP301S transgenic mice of both sexes. PubMed:29540553

Appears in Networks:
Annotations
Uberon
hippocampal formation

Out-Edges 1

a(HBP:"Pathological Tau Spreading") negativeCorrelation act(p(HGNC:SIRT1)) View Subject | View Object

SIRT1 deficiency exacerbates premature mortality, synapse loss, and behavioral disinhibition in tauP301S TG mice of both sexes. SIRT1 overexpression into the hippocampus reduces acetylated K174 tau and significantly attenuates the spread of tau pathology into anatomically connected brain regions of tauP301S transgenic mice of both sexes. PubMed:29540553

Appears in Networks:
Annotations
Uberon
hippocampal formation

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.