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p(HGNC:MCM4)

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Entity

Name
MCM4
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways v1.0.0

Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation v1.0.0

In-Edges 5

complex(GO:"MCM complex") hasComponent p(HGNC:MCM4) View Subject | View Object

Appears in Networks:

complex(p(HGNC:FKBP5), p(HGNC:MCM4)) hasComponent p(HGNC:MCM4) View Subject | View Object

Appears in Networks:

complex(p(HGNC:MCM4), p(HGNC:MCMBP)) hasComponent p(HGNC:MCM4) View Subject | View Object

Appears in Networks:

a(PUBCHEM:135316034) decreases p(HGNC:MCM4) View Subject | View Object

In colon carcinoma, IPA analysis revealed 28 genes associated with the disease that were also modulated by Protandim treatment. Of these, the first 25 listed (89%) were regulated by Protandim in the opposing direction to that taken by the colon carcinoma disease process. PubMed:22020111

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

path(MESH:"Colorectal Neoplasms") increases p(HGNC:MCM4) View Subject | View Object

In colon carcinoma, IPA analysis revealed 28 genes associated with the disease that were also modulated by Protandim treatment. Of these, the first 25 listed (89%) were regulated by Protandim in the opposing direction to that taken by the colon carcinoma disease process. PubMed:22020111

Appears in Networks:

Out-Edges 2

p(HGNC:MCM4) increases bp(GO:"DNA replication initiation") View Subject | View Object

Perhaps most surprisingly, we found that FKBP51 interacted with MCM4 and MCMBP (Figure 3B), two subunits of the MCM complex that are involved in DNA replication initiation and fork progression PubMed:25036637

Appears in Networks:

p(HGNC:MCM4) increases bp(GO:"replication fork progression beyond termination site") View Subject | View Object

Perhaps most surprisingly, we found that FKBP51 interacted with MCM4 and MCMBP (Figure 3B), two subunits of the MCM complex that are involved in DNA replication initiation and fork progression PubMed:25036637

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.