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bp(HBP:neurotoxicity)

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Entity

Name
neurotoxicity
Namespace
HBP
Namespace Version
20181128
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/7e4be528f12abd28be768b62402fba6e083eaf9e/export/hbp-names.belns

Appears in Networks 4

M1 muscarinic acetylcholine receptor in Alzheimer’s disease v1.0.0

This file encodes the article M1 muscarinic acetylcholine receptor in Alzheimer’s disease by Jiang et al, 2014

Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs) v1.0.1

Tau oligomers and tau toxicity in neurodegenerative disease v1.0.0

Tau oligomers and tau toxicity in neurodegenerative disease by Ward et al., 2012

Clearance of Amyloid Beta and Tau in Alzheimer’s Disease:from Mechanisms to Therapy v1.0.1

In-Edges 6

bp(GO:"Wnt signaling pathway") decreases bp(HBP:neurotoxicity) View Subject | View Object

In addition to inhibiting Abeta generation, activation of M1 mAChR counteracts Abeta-induced neurotoxicity through the Wnt signaling pathway, as Abeta impairs the Wnt pathway and M1 mAChR stimulation inactivates GSK-3beta via PKC activation, stabilizes beta-catenin, and induces the expression of Wnt-targeting genes engrailed and cyclin-D1 for neuron survival PubMed:24590577

Appears in Networks:

act(p(HGNC:CHRM1)) increases bp(HBP:neurotoxicity) View Subject | View Object

In addition to inhibiting Abeta generation, activation of M1 mAChR counteracts Abeta-induced neurotoxicity through the Wnt signaling pathway, as Abeta impairs the Wnt pathway and M1 mAChR stimulation inactivates GSK-3beta via PKC activation, stabilizes beta-catenin, and induces the expression of Wnt-targeting genes engrailed and cyclin-D1 for neuron survival PubMed:24590577

Appears in Networks:

a(HBP:"Tau oligomers") positiveCorrelation bp(HBP:neurotoxicity) View Subject | View Object

Tau protein can form multiple quaternary structures in solution, and recent evidence suggests that small tau oligomeric species may play a critical role in the spread of tau pathology and neurotoxicity PubMed:29686391

Appears in Networks:

a(HBP:"Tau oligomers") increases bp(HBP:neurotoxicity) View Subject | View Object

Together, these findings support the hypothesis that tau oligomers are the toxic form of tau in neurodegenerative disease PubMed:22817713

Appears in Networks:
Annotations
Confidence
High
MeSH
Intracellular Space

a(HBP:"Tau oligomers") increases bp(HBP:neurotoxicity) View Subject | View Object

This indicates that tau oligomers represent the main toxic species responsible for neurodegeneration associated with AD PubMed:22817713

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Intracellular Space

p(HGNC:MAPT, frag("?")) increases bp(HBP:neurotoxicity) View Subject | View Object

However, there was a study indicating that calpain-mediated tau cleavage can result in the generation of tau fragments, which may possess neurotoxicity in AD (Ferreira and Bigio 2011) PubMed:29626319

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

Out-Edges 1

bp(HBP:neurotoxicity) positiveCorrelation a(HBP:"Tau oligomers") View Subject | View Object

Tau protein can form multiple quaternary structures in solution, and recent evidence suggests that small tau oligomeric species may play a critical role in the spread of tau pathology and neurotoxicity PubMed:29686391

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.