a(HBP:"ACY-1215") directlyDecreases act(p(HGNC:HDAC6))

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PubMed:24844691

In the present study, we tested the potential of two selective HDAC6 inhibitors, tubastatin A and ACY-1215, to rescue cognitive deficits in a mouse model of AD. We found that both tubastatin A and ACY-1215 alleviated behavioral deficits, altered amyloid-β (Aβ) load, and reduced tau hyperphosphorylation in AD mice without obvious adverse effects. Our data suggested that tubastatin A and ACY-1215 not only promoted tubulin acetylation, but also reduced production and facilitated autophagic clearance of Aβ and hyperphosphorylated tau.

Related Edges 6

• a(HBP:"ACY-1215") decreases a(CHEBI:"amyloid-beta")
• a(HBP:"Tubastatin A") directlyDecreases act(p(HGNC:HDAC6))
• a(HBP:"Tubastatin A") decreases a(CHEBI:"amyloid-beta")
• a(HBP:"Tubastatin A") decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
• p(FPLX:Tubulin, pmod(Ac)) negativeCorrelation act(p(HGNC:HDAC6))
• act(p(HGNC:HDAC6)) negativeCorrelation p(FPLX:Tubulin, pmod(Ac))

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