Title

Tubastatin A/ACY-1215 improves cognition in Alzheimer's disease transgenic mice.

Journal

Journal of Alzheimer's disease : JAD

Volume

41

Issue

None

Pages

1193-205

Date

2014-01-01

Authors

Huang L | Liu C | Qin C | Sheng SL | Sui XL | Tao JJ | Wu J | Xu YF | Yao ZG | Zhang L | Zhu H

In the present study, we tested the potential of two selective HDAC6 inhibitors, tubastatin A and ACY-1215, to rescue cognitive deficits in a mouse model of AD. We found that both tubastatin A and ACY-1215 alleviated behavioral deficits, altered amyloid-β (Aβ) load, and reduced tau hyperphosphorylation in AD mice without obvious adverse effects. Our data suggested that tubastatin A and ACY-1215 not only promoted tubulin acetylation, but also reduced production and facilitated autophagic clearance of Aβ and hyperphosphorylated tau.

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