a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29))

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PubMed:16566606

Select nitration of residues Tyr18, Tyr29, Tyr197, and Tyr394, events known to stabilize the pathological Alz-50 conformation inhibits the ability of monomeric tau to promote tubulin assembly, effect specific for the 3-NT modification, as mutant tau proteins pseudophosphorylated at each Tyr residue are fully competent to stabilize MTs, suggesting that ONOO(-)-mediated modifications stabilize tau filaments via 3,3'-DT bonding and destabilize MTs by site-selective nitration of tau monomers.

Related Edges 19

• a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18))
• a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197))
• a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394))
• a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394))
• a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18))
• a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29))
• a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197))
• act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18))
• act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197))
• act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29))
• act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394))
• p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation a(HBP:"paired helical filaments")
• p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) negativeCorrelation act(p(HGNC:MAPT))
• p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) positiveCorrelation a(HBP:"paired helical filaments")
• p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) negativeCorrelation act(p(HGNC:MAPT))
• p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation a(HBP:"paired helical filaments")
• p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) negativeCorrelation act(p(HGNC:MAPT))
• p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) positiveCorrelation a(HBP:"paired helical filaments")
• p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) negativeCorrelation act(p(HGNC:MAPT))

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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