p(HGNC:ADAM17) increases a(HBP:HBP00067)

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PubMed:22122372

However, although sAPP-alpha generation is not affected in ADAM9/17 knock-down cell lines nor in mice carrying deficient ADAM9/17 genes (Weskamp et al. 2002; Kuhn et al. 2010), over-expression of ADAM9/17 does increase the level of sAPP-alpha under some conditions, suggesting that ADAM9 and ADAM17 are more likely involved in the regulated alpha-cleavage of APP rather than in constitutive alpha-cleavage

Related Edges 1

• p(HGNC:ADAM9) increases a(HBP:HBP00067)

Confidence

High

MeSH

Neurons

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