bp(GO:"one-carbon metabolic process") decreases act(a(CHEBI:"amyloid-beta"))

View Subject View Object

PubMed:24653673

Remarkably, impairment of one-carbon metabolism in animal models can reproduce AD-like pathological features: accumulation of P-tau (Sontag et al.,2007; Zhang et al.,2008; Wei et al.,2011); enhanced amyloidogenesis (Pacheco-Quinto et al.,2006; Zhang et al.,2009; Zhuo et al.,2010; Zhuo and Pratico,2010); increased phosphorylation of APP at the regulatory Thr-668 site (Sontag et al.,2007; Zhang et al.,2009); increased sensitivity to amyloid toxicity (Kruman et al.,2002); and cognitive impairment (Bernardo et al.,2007; Wei et al.,2011; Rhodehouse et al., 2013).

Related Edges 4

• bp(GO:"one-carbon metabolic process") decreases p(HGNC:MAPT, pmod(Ph))
• bp(GO:"one-carbon metabolic process") decreases bp(HBP:amyloidogenesis)
• bp(GO:"one-carbon metabolic process") decreases p(HGNC:APP, pmod(Ph, Thr, 668))
• bp(GO:"one-carbon metabolic process") decreases bp(GO:cognition)

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---