bp(GO:"microglial cell activation") positiveCorrelation act(p(HGNC:SYK))

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PubMed:28877763

To investigate whether pathological Syk activation oc- curs in the brain of AD mouse models, we analyzed the brains of 116-week-old wild-type, Tg APPsw and Tg PS1/APPsw mice using high-resolution confocal micros- copy and immunofluorescence. All transgenic mice (Fig. 1b-e) exhibit an increased Iba-1 and GFAP reactiv- ity compared to wild-type littermates (Fig. 1a). Moreo- ver,wild-type some of the activated amoeboid microglia that are observed in transgenic mice are also strongly positive for pSyk (Fig. 1b-d).

Related Edges 2

• act(p(HGNC:SYK)) positiveCorrelation bp(GO:"microglial cell activation")
• path(MESH:"Alzheimer Disease") increases bp(GO:"microglial cell activation")

MeSH

Brain

MeSH

Alzheimer Disease

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