p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases bp(GO:"neurofibrillary tangle assembly")

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PubMed:17493042

The lysine-isoleucine-glycineserine motif (KIGS) or lysine-cysteineglycine-serine motif (KCGS) motifs in the repeat domain (S262, S293, S324, S356) can be phosphorylated by MARK, PKA, SAD kinases, CaMKII and p70S6K, which strongly reduces the tau microtubule interactions (36, 74, 96), [note that phosphorylation at these sites also inhibits tau aggregation, illustrating an analogous role for the repeat domain in the physiological and pathological functions of tau (106)].

Related Edges 7

• p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins))
• p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases bp(GO:"neurofibrillary tangle assembly")
• p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins))
• p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins))
• p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases bp(GO:"neurofibrillary tangle assembly")
• p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins))
• p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases bp(GO:"neurofibrillary tangle assembly")

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