a(CHEBI:choline) decreases complex(p(HGNC:CHRNA7), p(HGNCGENEFAMILY:"G protein subunits beta"))

View Subject View Object

PubMed:26088141

As shown in Fig. 8, A and B, IP of the α7 using the C-20 antibody suggests that choline application attenuates G protein binding with the nAChR. Choline treatment resulted in a 56% reduction in Gαq and 47% reduction in Gβ association within the α7 nAChR complex (Fig. 8B).

Related Edges 2

• a(CHEBI:choline) decreases complex(p(FPLX:"G_protein"), p(HGNC:CHRNA7))
• a(CHEBI:choline) decreases complex(p(HGNC:CHRNA7), p(HGNC:GNAQ))

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---