p(HGNC:YWHAZ) increases act(p(HGNC:GSK3B))

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PubMed:12551948

In cells that were co-transfected with fixed amounts of FLAG-tau and HA-GSK3Beta but different amounts of Xpress-14-3-3zeta, FLAG-tau phosphorylation increased progressively with the increase in the amount of Xpress-14-3-3zeta (lanes 7–9). This increase was evident not only by an increased immunoreactivity against all tau phosphorylation-sensitive antibodies tested but also by a retarded mobility of FLAG-tau on the SDS gel, a characteristic feature of hyperphosphorylated tau (2, 3). Thus, 14-3-3zeta profoundly stimulated GSK3Beta-catalyzed tau phosphorylation in vivo.

Related Edges 1

• act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(Ph))

Experimental Factor Ontology (EFO)

HEK293

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