a(HBP:HBP00093) increases a(CHEBI:"calcium(2+)")

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PubMed:27075649

1 nM (Fig. 3a, right panels and Fig. 3b, red curve, solid line) and 0.2 nM α -syn fibrils (Fig. 3b, red curve, dashed line) induced a progressive and significant increase of intracellular Ca2+ levels, as revealed by the rise of Fluo-4 fluorescence in exposed SH-SY5Y cells. In contrast, only a modest Ca2+ increase was observed in cells exposed to 300 nM on-fibrillar assembly pathway oligomeric α -syn (Fig. 3a, middle panels and Fig. 3b, blue curve, solid line) or 10 μM monomeric α -syn (Fig. 3a, left panels and Fig. 3b, black curve, solid line).

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• a(HBP:HBP00092) increases a(CHEBI:"calcium(2+)")

MeSH

Intracellular Space

Cell Ontology (CL)

neuron

Confidence

Medium

MeSH

Lewy Bodies

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