a(MESH:"Receptors, N-Methyl-D-Aspartate") decreases a(HBP:HBP00063)

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PubMed:22122372

The levels of APP isoforms with a KPI domain seem to be elevated in patients with AD (Menendez- Gonzalez et al. 2005) and a splicing shift in neurons from APP695 to KPI-containing APP isoforms, along with increased Abeta generation, is observed when the NMDA receptor is activated (Bordji et al. 2010)

Related Edges 6

• a(HBP:HBP00064) positiveCorrelation path(MESH:"Alzheimer Disease")
• a(HBP:HBP00065) positiveCorrelation path(MESH:"Alzheimer Disease")
• a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(HBP:HBP00064)
• a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(HBP:HBP00065)
• path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00064)
• path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00065)

Confidence

Medium

MeSH

Neurons

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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