act(p(HGNC:KAT2B)) positiveCorrelation act(p(FPLX:ERK))

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PubMed:24686445

Here we show through systematic epigenetic studies that the histone acetyltransferase p300/CBP-associated factor (PCAF) promotes acetylation of histone 3 Lys 9 at the promoters of established key regeneration-associated genes following a peripheral but not a central axonal injury. Furthermore, we find that extracellular signal-regulated kinase (ERK)-mediated retrograde signalling is required for PCAF-dependent regenerative gene reprogramming. Finally, PCAF is necessary for conditioning-dependent axonal regeneration and also singularly promotes regeneration after spinal cord injury.

Related Edges 9

• a(HBP:"peripheral nervous system injury") increases p(HGNC:NGF)
• act(p(FPLX:ERK)) positiveCorrelation act(p(HGNC:KAT2B))
• p(FPLX:ERK, pmod(Ph)) increases act(p(FPLX:ERK))
• p(HBP:"Histone H3", pmod(Ac, Lys, 9)) increases r(HGNC:GAP43)
• p(HBP:"Histone H3", pmod(Ac, Lys, 9)) increases r(HGNC:GAL)
• p(HBP:"Histone H3", pmod(Ac, Lys, 9)) increases r(HGNC:BDNF)
• act(p(HGNC:KAT2B)) increases p(HBP:"Histone H3", pmod(Ac, Lys, 9))
• p(HGNC:NGF) increases p(FPLX:ERK, pmod(Ph))
• p(HGNC:NGF) increases act(p(HGNC:KAT2B))

Uberon

dorsal root ganglion

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