bp(MESH:Neuroprotection) association p(HGNC:FYN)

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PubMed:19293145

From these findings, it would seem that FYN plays a neuroprotective role. However, FYN may also play a paradoxical role in Abeta toxicity. Indeed, Abeta activates both FYN and the PI3K cascade (Williamson et al., 2002), whereas germline knockout of FYN is neuroprotective in mice (Lambert et al., 1998; Chin et al., 2004). FYN knockout protects mature mouse neurons in organotypic central nervous system cultures (Lambert et al., 1998).

Related Edges 6

• act(a(CHEBI:"amyloid-beta")) association p(HGNC:FYN)
• a(CHEBI:"amyloid-beta") increases act(p(HGNC:FYN))
• a(CHEBI:"amyloid-beta") increases act(p(FPLX:PI3K))
• p(HGNC:FYN) association bp(MESH:Neuroprotection)
• p(HGNC:FYN) association act(a(CHEBI:"amyloid-beta"))
• p(MGI:Fyn) decreases bp(MESH:Neuroprotection)

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