a(CHEBI:"amyloid-beta") increases act(p(HGNC:FYN))

View Subject View Object

PubMed:19293145

From these findings, it would seem that FYN plays a neuroprotective role. However, FYN may also play a paradoxical role in Abeta toxicity. Indeed, Abeta activates both FYN and the PI3K cascade (Williamson et al., 2002), whereas germline knockout of FYN is neuroprotective in mice (Lambert et al., 1998; Chin et al., 2004). FYN knockout protects mature mouse neurons in organotypic central nervous system cultures (Lambert et al., 1998).

Related Edges 6

• act(a(CHEBI:"amyloid-beta")) association p(HGNC:FYN)
• a(CHEBI:"amyloid-beta") increases act(p(FPLX:PI3K))
• bp(MESH:Neuroprotection) association p(HGNC:FYN)
• p(HGNC:FYN) association bp(MESH:Neuroprotection)
• p(HGNC:FYN) association act(a(CHEBI:"amyloid-beta"))
• p(MGI:Fyn) decreases bp(MESH:Neuroprotection)

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---