p(HGNC:MAPT, frag("1_421")) increases a(GO:"neurofibrillary tangle")

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PubMed:26631930

In human AD brains and in the Tg4510 tauopathy mouse model, full-length tau is cleaved by caspase 3 behind Asp421 to generate tau1–421, which is prone to aggregation and subsequent formation of NFTs

Related Edges 2

• p(HGNC:CASP3) increases p(HGNC:MAPT, frag("1_421"))
• p(HGNC:MAPT, frag("1_421")) increases a(HBP:"Tau aggregates")

MeSH

Brain

MeSH

Alzheimer Disease

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