complex(GO:"proteasome complex") increases deg(a(CHEBI:"amyloid-beta"))

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PubMed:14556719

It has been shown that Abeta can be degraded by the proteasome in cultured neurons and astrocytes, and reatment with the proteasome inhibitor lactacystin decreased viability of cells exposed to Abeta (Lopez Salon et al., 2003).

Related Edges 2

• a(CHEBI:lactacystin) decreases act(complex(GO:"proteasome complex"))
• a(CHEBI:lactacystin) increases bp(GO:"cell death")

Cell Ontology (CL)

astrocyte

Cell Ontology (CL)

neuron

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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