a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph))

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PubMed:24653673

In vivo use of phosphatase inhibitors such as okadaic acid has been shown in many studies to induce cognitive impairment and widespread neurotoxic effects that are reminiscent of the hallmark pathological processes occurring in AD pathology, i.e., the accumulation of P-tau, amyloidogenesis, synapse loss and neurodegeneration (Malchiodi-Albedi et al., 1997; Arendt et al., 1998; Sun et al.,2003; Kamat et al.,2013)

Related Edges 5

• a(CHEBI:"okadaic acid") decreases act(complex(GO:"protein phosphatase type 2A complex"))
• a(CHEBI:"okadaic acid") decreases bp(GO:cognition)
• a(CHEBI:"okadaic acid") increases bp(HBP:amyloidogenesis)
• a(CHEBI:"okadaic acid") decreases a(GO:synapse)
• a(CHEBI:"okadaic acid") increases path(HBP:Neurodegeneration)

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