m(MIRBASE:"hsa-mir-125b-1") decreases p(HGNC:VDR)

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PubMed:27288790

Pathogenic effects appear to be mediated via specific interaction of miRNA-125b with the 3′-UTR region of mRNA of 15-lipoxygenase (15-LOX) and the vitamin D3 receptor (VDR; VD3R), the downregula- tion of 15-LOX and VDR may therefore be explained by the actions of a single inducible, pro-inflammatory miRNA-125b in hippocampal CA1 of AD brain [71].

Related Edges 3

• m(MIRBASE:"hsa-mir-125b-1") decreases p(HGNC:ALOX15)
• m(MIRBASE:"hsa-mir-125b-2") decreases p(HGNC:ALOX15)
• m(MIRBASE:"hsa-mir-125b-2") decreases p(HGNC:VDR)

MeSH

CA1 Region, Hippocampal

MeSH

Alzheimer Disease

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