path(MESH:"Neurofibrillary Tangles") positiveCorrelation p(HGNC:CAPN2)

View Subject View Object

PubMed:24027553

The active form of calpain-2 is found in 50–75% of NFTs in tauopathies including AD, but not in protein aggregates found in other diseases (47). This is consistent with another study that found equivalent calpain levels between control and AD cases, but the activity level of the enzyme isolated from AD brain tissue was increased (48).

Related Edges 2

• p(HGNC:CAPN2) positiveCorrelation path(MESH:"Neurofibrillary Tangles")
• path(MESH:"Alzheimer Disease") increases act(p(HGNC:CAPN2))

MeSH

Alzheimer Disease

MeSH

Tauopathies

Text Location

Review

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---