p(HGNC:CAPN2) positiveCorrelation path(MESH:"Neurofibrillary Tangles")

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PubMed:24027553

The active form of calpain-2 is found in 50–75% of NFTs in tauopathies including AD, but not in protein aggregates found in other diseases (47). This is consistent with another study that found equivalent calpain levels between control and AD cases, but the activity level of the enzyme isolated from AD brain tissue was increased (48).

Related Edges 2

• path(MESH:"Alzheimer Disease") increases act(p(HGNC:CAPN2))
• path(MESH:"Neurofibrillary Tangles") positiveCorrelation p(HGNC:CAPN2)

MeSH

Alzheimer Disease

MeSH

Tauopathies

Text Location

Review

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