path(MESH:Tauopathies) negativeCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))

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PubMed:24653673

Notably, the loss of neuronal PP2A/Bα holoenzymes correlates with the down-regulation of PP2A methylation and severity of phosphorylated tau (P-tau) pathology in AD-affected brain regions (Sontag et al.,2004 a,b).

Related Edges 5

• complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) positiveCorrelation p(FPLX:PPP2, pmod(Me))
• complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) positiveCorrelation p(FPLX:PPP2, pmod(Me))
• complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) negativeCorrelation path(MESH:Tauopathies)
• p(FPLX:PPP2, pmod(Me)) positiveCorrelation complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))
• p(FPLX:PPP2, pmod(Me)) positiveCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))

MeSH

Alzheimer Disease

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