p(HGNC:APP, frag("672_713")) increases path(MESH:"Plaque, Amyloid")

View Subject View Object

PubMed:21214928

Studies done on familial AD (FAD) mutations consistently show increases in the ratio of Abeta42/40 [105,144], suggesting that elevated levels of Abeta42 relative to Abeta40 is critical for AD pathogenesis, probably by providing the core for Abeta assembly into oligomers, fibrils and amyloidogenic plaques [145,146]

Related Edges 3

• p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00038)
• p(HGNC:APP, frag("672_713")) increases path(MESH:"Alzheimer Disease")
• p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00022)

MeSH

Endosomes

Confidence

High

MeSH

Neurons

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---