p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00022)

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PubMed:21214928

Studies done on familial AD (FAD) mutations consistently show increases in the ratio of Abeta42/40 [105,144], suggesting that elevated levels of Abeta42 relative to Abeta40 is critical for AD pathogenesis, probably by providing the core for Abeta assembly into oligomers, fibrils and amyloidogenic plaques [145,146]

Related Edges 3

• p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00038)
• p(HGNC:APP, frag("672_713")) increases path(MESH:"Alzheimer Disease")
• p(HGNC:APP, frag("672_713")) increases path(MESH:"Plaque, Amyloid")

MeSH

Endosomes

Confidence

High

MeSH

Neurons

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