bp(GO:macroautophagy) increases deg(p(MGI:Mapt))

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PubMed:29024336

In this study, we analyzed the contribution of three different types of autophagy, macroautophagy, chaperone-mediated autophagy, and endosomal microautophagy to the degradation of tau protein variants and tau mutations associated with this agerelated disease. We have found that the pathogenic P301L mutation inhibits degradation of tau by any of the three autophagic pathways, whereas the risk-associated tau mutation A152T reroutes tau for degradation through a different autophagy pathway

Related Edges 4

• bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt))
• bp(GO:"late endosomal microautophagy") increases deg(p(MGI:Mapt))
• p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt))
• p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt))

Confidence

High

MeSH

Brain

MeSH

Neurons

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