a(CHEBI:heme) increases p(HGNC:TNF)

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PubMed:26875449

Taken sequentially, it appears that the release of heme under hemolytic conditions initiates the extrinsic pathway of coagulation through the upregulation of TF on endothelial cells and leukocytes, but subsequently blocks the propagation of coagulation by inhibiting FVIII and FV, and by inhibiting the conversion of fibrinogen into fibrin and fibrin clots.

Related Edges 5

• a(CHEBI:heme) decreases p(HGNC:F8)
• a(CHEBI:heme) decreases a(MESH:Fibrin)
• a(CHEBI:heme) positiveCorrelation bp(GO:"blood coagulation, extrinsic pathway")
• a(CHEBI:heme) decreases p(HGNC:F5)
• bp(GO:"blood coagulation, extrinsic pathway") positiveCorrelation a(CHEBI:heme)

MeSH

Anemia, Sickle Cell

Text Location

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